This paper was published in Measurement Science and Technology and is made available as an electronic reprint with the permission of IOP. The paper can be found at the following URL on the IOP website: http://www.iop.org/EJ/journal/MSTInternational audienceThe potential of in-line digital holography to locate and measure the size of particles distributed throughout a volume (in one shot) has been established. These measurements are fundamental for the study of particle trajectories in fluid flow. The most important issues in digital holography today are poor depth positioning accuracy, transverse field-of-view limitations, border artifacts and computational burdens. We recently suggested an ‘inverse problem' approach to address some of thes...